Maybe, but it looks like each leader progresses on the same, generic skill sets, and the bonuses aren't particularly immersive, just a plus here and a plus there. Agreed that provides min-maxers the ability to better stack bonuses to create "look at this!" screen shots, but not sure how differently each leader will play if you're not purposefully trying to stack bonuses.
Leaders apparently also have unique events, so maybe those will create more uniqueness to choosing one over another. I'm personally more interested in how differently games play based on having leader X instead of leader Y as my closest neighbour. So far, I'm not seeing anything that would cause the different leaders to behave differently, but we won't know for sure until we see everything in action.