Boris Gudenuf
Deity
But he did it by conquestEven his attempts to merge Greek and Persian culture were ham-handed, as far as the record allows us to see. It's a miracle his empire survived his death in any number of pieces.
And I would say, "doing it by conquest" as Alexander did became the Model for a host of others throughout subsequent history. Whether that's a good or bad thing is historically irrelevant (or, more accurately, it's goodness of badness depends on which end of the Conquest Stick you are on). Alexander made no attempts to merge Greek and Persian Culture, he made attempts to merge Greek and Persian people into a Ruling Class from which he could draft governors and satraps and others needed to run his empire. The cultural fusion happened more as a result of a massive influx of Greeks into the Middle East as a result of his conquests, which in turn resulted in the spread of Greek philosophical thinking throughout. So much so, that you can write books on the influence of Greek Cynic and Stoic philosophy on early Christianity - Greek influences in thinking that permeated Palestine and the areas around it 300 years after Alexander's death.
His Empire, of course, did not survive his death. But the Idea of his empire survived in the form of the Diadochi or Successors of Alexander, who formed Macedonian/Greek/Persian/Egyptian/Bactrian states and empires lasting in some cases a century or more after his death as political/military entities. The influence of his conquests in culture was indirect but more lasting, and the influence of his city founding and siting lasts to the present day in those cities, even though none of them show the slightest Macedonian or Greek physical or cultural influences any more.