See why I love Civ4? It has every branch of academics and beyond under one umbrella. I grew up with a strong science/math academics but got bored with them alone in college career. Right now, I'm aiming at becoming a history professor at Gallaudet University one day. Because i got bored with specific social science subjects alone. Finally I found what I needed: history! History is only subject in academics that can synthesize all other subjects under one roof.
Not related to my future career, but my hope is that historians will inspire future social and natural scientists to work together such that the divisions of these become practically non-existent except in formal documents.
I had to say this because of a fascinating discussion going on here

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I don't know how many "academics" play civ. I know plenty of kids my age who play, but nobody with any real scholarly responsibility. I myself have been studying astronomy and physics for the last three years but I'm hardly an academic. Instead of putting enough time into understanding physics I've sank it all into 4 categories: beer, women, rugby and Civ. Fortunately astronomy is easy enough to get away with that, but not physics. I can't speak for everybody though, I'm sure there's plenty of other achievers like you out there that get their civ on as well.
the day that the first real AI is created will be the day when social and natural sciences will certainly merge. at the one hand psychology and social studies can found all their theories on the basic model of an intelligence and derive all properties form it's basic structure. at the other hand a source code is enough for nature sciences to build a formal model for further of a mind that they can work with.
Yes, Hard AI will change everything. If you've ever heard of Ray Kurzweil, he's made some bold predictions about the rate of increase of technology. He's a smart sonn'of'a'birch, and worth looking into with an open mind, but somewhat skeptical eye.
According to him, by 2029 we'll have hard AI that can pass the turing test
And in 2045:
"$1000 buys a computer a billion times more intelligent than every human combined. This means that average and even low-end computers are vastly smarter than even highly intelligent, unenhanced humans."
Imagine playing civ on that
I don't think the future will be men and women riding in spaceships to explore the galaxy; I think machine intelligence will replace human intelligence as far as technological progress goes (probably not forcefully, ie Terminator). Exponential expansion of the humanity's technology means space may be conquered pretty uneventfully and pretty fast by self replicating intelligent robot probes.
As far as extraterrestial intelligence goes there are a few options:
1) It either doesn't exist locally
2) It's tech hasn't exploded exponentially, or they never choose to expand into space
3) Intelligent machines permeate the galaxy, possibly the universe, but remain hidden. They use communication techniques which are superior to radio or any EM signal.
This forum has deviated pretty far off topic from the creator's intention for the mod though. Perhaps it should be moved.
My suggestions from this discussion as related to Ascent of Mankind:
The tech race for AI. Honestly by the time we have AI in our world though, the nation state is going to be a nearly extinct concept; but maybe for civ purposes it isn't. Hard AI can either give you nearly unlimited research and production power...
Or it can backfire and spawn a "barbarian" robot legion in the city that built the AI. Included might be a few dozen fusion nova nukes. The civ AI targets all players' capital cities, and goes through the list 3-5 times, thus wiping out most of your important cities, causing massive upheaval if revolutions are turned on.
As for space travel and colonization, that can occur if you don't have a 'terminator event' or if you destroy the threat and move on.
Again though, should we move this discussion?