What is the full path of your Test of Time directory? Did you try running the TOTPP launcher as Administrator? or try running it in XP compatibility mode? Could your anti-virus program be blocking the launcher? Can you temporarily disable that and try it then? You might need to try various combinations of the above, if there are multiple issues. Can you start a new game (without TOTPP) and play normally for several turns, just using the normal executable? I think the very first time you run the launcher, it actually edits and rewrites the civ2.exe executable. That's different from when you run it the second and following times, so you may need more enhanced permissions (or something) in order to make that initial change -- different from what is required to run the game (with TOTPP) afterwards. Problems like this aren't easy to troubleshoot in a forum like this, since the problem can be so machine-specific. I hope one of the above ideas helps, or at least reveals more details about the issue.