I'm playing now with some of the terrain in East Asia edited, to be what I think is correct. Game runs fine, loading is fine, but REloading starts to get CTD around turn 40. I play at Marathon speed. I also get the leader/team mix up the first time aroudn. I reorganised the team numbers and colours (playable civs 1 - 18, city states 19+) and now it's so far so good.