The new American core/tile arrangement is overall solid. I do think there's one tweak I would make, which is to move the Erie and Cleveland tiles one east, eliminate the city name "Jamestown" (in this context, Jamestown is a tiny town in upstate NY that nobody has heard of) and then you're left with a tile between Cleveland and Toledo that could be Lorain or Sandusky but shouldn't normally be settled because it's too close to canon Detroit and Cincinnati. This allows Cleveland or Pittsburgh, Detroit and Cincinnati as the ideal layout for the American core after Washington, New York and Boston, which is pretty good, and also aligns with the rest of the map (Erie directly north of Pittsburgh, Cleveland directly north of Akron). I think right now maybe Buffalo is intended as canon over Cleveland/Pittsburgh, which isn't terrible either, but it makes sense to have a few canon options in the region.
Even with the resource changes, the Jamestown tile (renamed Erie per the above) is probably stronger than [old Erie, new Cleveland] or Pittsburgh since it can compete with Toronto for the Lake Ontario tiles, so maybe a resource should be moved onto that tile to make it undesirable to settle. Alternatively maybe make that tile Pittsburgh and Pittsburgh becomes clearly the canon choice, but that does leave a hole to its south and of course Pittsburgh is not on Lake Erie, so it's not an ideal solution.