I started a new game with Ancient at 60, Classical at 75, and Med at 90. With these settings I did not have my 1st city or 1st 2 cities devastated by the Health event (-1 pop with successful outcome), because generally my city/cities have just reached pop 2 when this event likes to pop up.
You can't compare C2C with AND on these values because AND does Not have the building choices C2C has. And Needs a less restrictive Ancient era for igrowth than C2C.
Warning: OT Rant
Quite frankly AND is boring for the 1st 200/300 turns (on Epic or Marathon) because you have very little to build or improve, limited Gold/Commerce, and too high maintenance costs for city, units, and civics (in that order). Build more than a handful of units or more than 3 cities and you drown in -Gold and research slider at < 30%. You Must have an extremely good starting location to get above this. Now add in that Civic changes in Ancient and Classical (till you build National Courier Wonder) is 3 turns of anarchy for every Civic change. This is too much too! And finally the Poly/Mono/Buddha Religion tech line Must be broken up as well as the kemet/zorast. 1 civ will generally found at least 3 of these starting 5 religions, but sometimes all. And it's all because of How the tech progress is set up. A few simple Preq Tech changes and the religions will get spread out and then Limited Religion Option becomes Unneeded because the original complaint of 1 AI or player hogging all the religions is Gone! These are some of the issues I had with Afforess and AND back in the day, that impho still exist for no good real reason (in my estimation anyway).
Okay rant over, just had to get that off my chest.
JosEPh