The only thing that puts me on the fence about that is Maria Theresa was empress-consort of the Holy Roman Empire--but in the end I'd be okay with it because everyone knew who wore the pants in that relationship (and it wasn't Francis--she'd literally send him out of the room if he disagreed with her in public).
As someone who has frequently requested Zenobia, I'd point out that the Palmyrene Empire was not the only important Aramaic-speaking polity in Syria. Zenobia solves the problem that none of the Aramaic kingdoms had very interesting leaders, and the Aramaic kingdoms solve the problem that Zenobia's Palmyrene Empire was independent only briefly (though she was the de facto ruler of Roman Asia for a considerably longer period). I'd like to see her civilization called Aram (or even Syria, if necessary).
It would solve the problem of Syria somehow never getting on "great civilizations" list and in such games, despite Aleppo and Damascus being probably the oldest continuously occupied cities in the world, despite Syria being among cradles of civilization, and despite having huge cultural influence.
It even had few big states for a while (Yamhad based on Aleppo, Mari, Ebla...) which were tier 1 powers of the Middle East.