Genetic engineering, circa 1626 A.D.
"By art likewise we make them greater or smaller than their kind is, and contrariwise dwarf them and stay their growth; we make them more fruitful and bearing than their kind is, and contrariwise barren and not generative. Also we make them differ in color, shape, activity, many ways. We find means to make commixtures and copulations of divers kinds, which have produced many new kinds, and them not barren, as the general opinion is. We make a number of kinds of serpents, worms, flies, fishes of putrefaction, whereof some are advanced (in effect) to be perfect creatures, like beasts or birds, and have sexes, and do propagate. Neither do we this by chance, but we know beforehand of what matter and commixture, what kind of those creatures will arise."
-the Head of Salomon's House, in
New Atlantis by Sir Francis Bacon
Genuinely disturbing (italics by author)
"We could believe that
we are somehow wrong about the nature of everything that surrounds us. The world of conventional objects which the being with the arm describes is not subject to the conventional and comprehensible laws we believe it to be. Its dream-logic about ovens and cakes and casts and invulnerability is
the way the world works, not a deluded fantasy by a buried giant. The Foundation's attempts to rigorously study it are futile, because reason itself is a bizarre delusion. This is the most horrible answer, and what I'm trying to get at."
-ophite, discussion on
SCP-1193