Newsworthy Science

Oh wow. Living in vitro brain cells have been taught to play the video game "Pong" :thumbsup:

 
Nature's got an article with a slightly clearer take on it here:

https://www.nature.com/articles/d41586-021-00462-9





While I'm raising a dubious eyebrow to the claim that 5-10% of the genome is "missing", the existing sequencing technologies do struggle with sections of DNA with many repeats of the same sequence. Since current methods rely on chopping the DNA into 1000+ fragments, and then sticking them back together by matching up the overlapping ends of each section, it's possible to lose, say, some of the middle repeats. Sure, the sequencing will provide the sequence of the repeating unit, and which other gene sequences it's sandwiched between. But as to how many repeats there are, sometimes the most that can be said is "at least X", simply because that's the longest individual fragment composed entirely of those repeats. There can also be similar problems if near identical sequences appear in different parts of the genome.

The nanopore technology's selling point seems to be that it can read much longer individual fragments - indeed they seem to have a goal of a literal end to end scan of the genome in one go, although they're not there yet. In principle that would pin down issues like how many repeats there are, how much it varies from person to person (and even from cell to cell). There are some medical conditions which can be caused by abnormal numbers of repeats in these kinds of sections of DNA (usually excessive numbers). They're not just problematic for us to sequence, they're weak links for the body's own DNA handling systems for somewhat related reasons. Hence potentially pathologically relevant.

I agree with Samson that the reporter in the previous article has got horribly confused between these kind of problematic sequences, individual nucleotide variation, and (probably?) DNA methylation - based on the description of attaching things to DNA.
I'd still need to google the company from BJs article, but yeah, this seems to be pretty much Nanopore technology.

The 5-10% seems to be adequate, we have now a fully closed genome and I think remember reading that number.

The Nanopore technology has also another couple of advantages, like being able to detect methylation/epigenetics (although Pacific Biosciences technology can do that too), it can natively read RNA, and there's been a proof of concept recently that you can also read peptides with it.
Overall an interesting technology.

EDIT: And yes, the reporter from the article really mixed things up badly. But it's a complicated area of science, it doesn't surprise me that much.

EDIT2: Seems ArmonicaTech is indeed using a similar technology as Oxford Nanopore, but it's reading the data not via the electrical current in the nanopore, but rather by Raman Spectroscopy. Okay, fine as well, I'm okay with that :D. Definitely not as revolutionary as described in the article. But will be good to have another company in this field. DNA sequencing is pretty much an oligopol, more competition should be better.
 
Childhood adversity can cast a long shadow

In the late 1980s, a Kaiser Permanente clinic in San Diego teamed up with the Centers for Disease Control and Prevention to launch a groundbreaking study of adverse childhood experiences — ACEs.
The first paper produced by the ACE study was published in 1998. It has since been cited in the professional literature a staggering 17,645 times, according to Google Scholar.
The study itself is ongoing.

Meanwhile, its major findings have been replicated in countries around the world. Many states, including New Mexico, have launched ACE studies of their own populations. On the CDC’s website, you’ll find this brief description of the original study: “Over 17,000 Health Maintenance Organization members from Southern California receiving physical exams completed confidential surveys regarding their childhood experiences and current health status and behaviors.” The subjects were asked a series of detailed questions designed to establish whether, as children, they had experienced any one of 10 specific adversities. The adversities included abuse and neglect, as you’d expect, but also such disruptions as parental divorce or a parent’s incarceration. (You can get more information and read the questionnaires at www.cdc.gov/ violence prevention/aces/about. html) The researchers deliberately chose a conservative method of scoring the results. Respondents were assigned either a 1, if they had experienced a given adversity, or a 0, if they hadn’t, for a maximum ACE score of 10. Erring always on the side of undercounting, the researchers assigned a 0 if a respondent reported they had experienced certain adversities only once or rarely.
Of that original cohort of middle-class San Diegans, the largest group, 36.1%, reported zero ACEs. Somewhat fewer reported one ACE, and fewer still two or three, while 12.5% reported four or more.
Their ACE scores correlated, with stunning precision, to a long series of mental health problems. To quote from the abstract of the first of many papers, “Persons who had experienced four or more categories of childhood exposure, compared to those who had experienced none, had 4- to 12-fold increased health risks for alcoholism, drug abuse, depression, and suicide attempt.”

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Mental health issues might have been expected. But the researchers also found a “dose response relationship” between high ACE scores and purely physical ailments, conditions no one would describe as psychosomatic, including “ischemic heart disease, cancer, chronic lung disease, skeletal fractures, and liver disease.”


Addressing NM’s crime issues starts with safeguarding children

Other researchers, notably the late Bruce McEwen, have shown at a molecular level how chronic stress alters a developing child’s neural circuits and brain structures. A body chronically awash in stress hormones is changed by them. Those changes damage a person’s mental and physical health. They also influence his or her behavior, which is how this column dovetails with the last, which was concerned with the root causes of crime.

A 2016 study by the New Mexico Sentencing Commission reported that “experiencing childhood physical abuse and other forms of ACEs leads to higher rates of self-reported total offending, violent offending, and property offending.”
The study looked at all 220 juvenile offenders incarcerated in New Mexico in 2011. Instead of relying on self-reports, the researchers used multiple sources of information, including interviews with parents and guardians, plus medical and child protective service records, to calculate each child’s ACE score.

They found that less than 1% of the juveniles had an ACE score of zero. The incarcerated juveniles “were seven times more likely to have four or more ACEs (86% compared to 12%)” than the original San Diego cohort. Those are stark numbers.
The relationship of ACEs to criminal offending continues into adulthood. This August, a study in Academic Pediatrics reported that a high ACE score was “significantly associated with various forms of criminal justice contact during young and middle
adulthood, including having been arrested, experiencing a greater number of arrests, having been incarcerated in adulthood, having been incarcerated multiple times, and having spent longer periods of time incarcerated.” Poverty, the traditional “root cause of crime,” can contribute directly to a high ACE score when a child lacks food to eat and clean clothes to wear. But physical neglect is only one factor among many.

A recent Journal headline read: “Report: NM repeat abuse rate ‘among worst’ in US.” That article was, among other things, telling us about New Mexico’s future. Most kids who grow up in adversity don’t become offenders, of course. ACEs are not fate. But, on a society-wide level, the current shortcomings of child protective services will be reflected in future crime statistics. Or, to put it another way, the crimes reported in today’s Journal provide a partial accounting of the state’s failures from 10 and 20 years ago.

If we in New Mexico were serious about addressing the crime problem, we would start by safeguarding our children.

Joel Jacobsen is an author who, in 2015, retired from a 29-year legal career. If there are topics you would like to see covered in future columns, please write him at legal.column.tips@gmail.com.

JACOBSEN’S COUNSEL
Joel Jacobsen
 

Bird's 13,000-km, non-stop flight may be record-breaking​

Bird made transpacific trek from Alaska to Tasmania in just 11 days

A young bar-tailed godwit appears to have set a non-stop distance record for migratory birds by flying at least 13,560 kilometres from Alaska to the Australian state of Tasmania, a bird expert said Friday.
The bird was tagged as a hatchling in Alaska during the Northern Hemisphere summer with a tracking GPS chip and tiny solar panel that enabled an international research team to follow its first annual migration across the Pacific Ocean, Birdlife Tasmania convenor Eric Woehler said. Because the bird was so young, its gender wasn't known.
Aged about five months, it left southwest Alaska at the Yuko-Kuskokwim Delta on Oct. 13 and touched down 11 days later at Ansons Bay on the island of Tasmania's northeastern tip on Oct. 24, according to data from Germany's Max Plank Institute for Ornithology. The research has yet to be published or peer reviewed.
The bird started on a southwestern course toward Japan then turned southeast over Alaska's Aleutian Islands, a map published by New Zealand's Pūkorokoro Miranda Shorebird Centre shows.

May have been lost​

The bird was again tracking southwest when it flew over or near Kiribati and New Caledonia, then past the Australian mainland before turning directly west for Tasmania, Australia's most southerly state. The satellite trail showed it covered 13,560 kilometres without stopping.
"Whether this is an accident, whether this bird got lost or whether this is part of a normal pattern of migration for the species, we still don't know," said Woehler, who is part of the research project.
Guinness World Records lists the longest recorded migration by a bird without stopping for food or rest as 12,200 kilometres, which was covered by a satellite-tagged male bar-tailed godwit flying from Alaska to New Zealand.
That flight was recorded in 2020 as part of the same decade-old research project, which also involves China's Fudan University, New Zealand's Massey University and the Global Flyway Network.
The same bird broke its own record with a 13,000-kilometre flight on its next migration last year, researchers say. But Guinness has yet to acknowledge that feat.

Flight leaves scientists with questions​

Woehler said researchers did not know whether the latest bird, known by its satellite tag 234684, flew alone or as part of a flock.
"There are so few birds that have been tagged, we don't know how representative or otherwise this event is," Woehler said.
"It may be that half the birds that do the migration from Alaska come to Tasmania directly rather than through New Zealand or it might be one per cent, or it might be that this is the first it's ever happened."
Adult birds depart Alaska earlier than juveniles, so the tagged bird was unlikely to have followed more experienced travellers south, Woehler said.
Woehler hopes to see the bird once wet weather clears in the remote corner of Tasmania, where it will fatten up after having lost half its body weight on its journey.
https://www.cbc.ca/news/science/godwit-migration-alaska-tasmania-record-1.6632658
 

Bumblebees play with balls just for fun, study finds​

'There's more to bees than just being pollinators,' says study author. 'They're quite clever little creatures'

Bumblebees, it appears, are quite playful — especially when they're young.

A new study out of the U.K. found that if you give bumblebees tiny wooden balls, they'll spend time moving them around, seemingly just for fun. And the younger the bee, the more time they spend playing.

"We think it's rewarding," bee researcher Samadi Galpayage told As It Happens host Nil Köksal. "There's more to bees than just being pollinators. They have really interesting behaviours, actually, and they're quite clever little creatures."

Galpayage, a PhD student at Queen Mary University's Bee Sensory and Behavioural Sciences Lab in London, is the first author of a new study into the phenomenon. The findings were published last month in the journal Animal Behaviour.

Not about food or sex​

The researchers stumbled upon the behaviour while working on a different study, in which they trained bees to push balls in exchange for sugary treats.

But they noticed the playful pollinators kept on pushing the balls around even when they weren't getting rewarded.

"We saw this phenomenon and we wondered: What's happening here? Why are the bees doing this? Are there specific bees that are doing this? Do they do this repeatedly?" Galpayage said.

"And so we designed these new series of experiments to test whether this could be something like play."

In the new study, 45 bumblebees were given small wooden balls. This time, there was no reward system. The bees also had unrestricted access to an "all-you-can-eat" buffet of sucrose solution and pollen, Galpayage said.

Still — even with no incentives — they played.

Here's how it looks: A bee, Galpayage said, walks toward a ball and places its two front legs on it. Then, it rotates the ball until it's holding it in all six legs, almost as if hugging it.

Once the bee has a good grip on the ball, it scoots backwards on its butt and pulls the ball towards itself, rotating it along the way.

"Of course, I have to be objective," Galpayage said. "But, of course … I can't help but feeling amused by it."

The study focuses on balls, but the bees appear to enjoy all sorts of toys. Galpayage says she's observed the same behaviour after giving them bottles and foam cubes.

"So it's not so much about the object itself, but it seems to be the behaviour, the action of this rotation, that seems to be appealing to the bees."

This rotation, she said, is not something that bees would do when foraging food or collecting pollen, and they weren't getting treats for their tricks, so there's no indication this is food-motivated behaviour.

Nor do they appear to be trying to mate with the objects, she said. Female bees engaged in the play alongside males, even though only males and queens are involved in mating.

What's more, male genitalia does not make an appearance during this playful activity as it would during reproduction.

The 'rich sensory and cognitive life' of bees​

Still, food may still play an indirect role in explaining the behaviour, says beekeeper Shelley Hoover, a biological sciences researcher at Alberta's University of Lethbridge.

"Bees, particularly bumblebees, forage on diverse and complex flowers, and so need to be able to solve these flower puzzles to access the nectar rewards the flowers offer," she said in an email. "Learning is a very important part of being a good forager, and play is often associated with learning."

She says the study highlights yet another example of the complex inner workings of bumblebees.

"There are a number of important implications of the study, but to me the most important is that we are starting to recognize the rich sensory and cognitive life that bees lead," she said.

"Just like us, they use intelligence and learning to solve problems in their everyday life; they have preferences and personalities; and yes, they play."

Sheila R. Colla, a bumblebee ecologist at York University in Toronto, agrees.

"I think a main takeaway from this study is that there is still so much to learn about the insect world. Insects are more intelligent than we give them credit for," she said. "As a conservation scientist, I hope we keep pollinators around to be able to learn more from them."

Galpayage says bees already have a positive reputation among humans for their work as pollinators — but there's so much more about them to appreciate.

"I hope that with this sort of research — where we get at the questions of whether bees experience something like pleasure or something like pain — that maybe we start to feel more empathy towards bees and other insects," she said.

"A bit like we do with our pets or like larger animals that we protect."
https://www.cbc.ca/radio/asithappens/bumblebee-balls-play-study-1.6639406
 
Hydrogen production technology getting closer to road-ready
BY TROY SEMELSBERGER
CHEMICAL ENGINEER, LOS ALAMOS NATIONAL LABORATORY

The era of viable alternatives to fossil fuel-based transportation appears to be at hand. With the transportation sector the biggest contributor of greenhouse gases in the United States, California recently became the first of potentially many states to put a 2035 expiration on the sale of new internal combustion vehicles. Meeting climate-crisis driven transportation challenges depends on developing new fuels and an infrastructure for producing, processing, delivering and storing those fuels.

Hydrogen is a promising alternative fuel for vehicles, especially light trucks and heavy vehicles, given the constraints of battery-only vehicle power. The hydrogen fuel-cell technology to power those vehicles is rapidly advancing. A complementary challenge emerges: How do we get the hydrogen where it needs to be? Can we make fueling with emissionfree hydrogen as easy as filling up the tank on a gas guzzler? Recent research is making big strides toward finding solutions.
Gasoline and diesel can be easily transported in trucks and pipelines and stored in underground tanks for extended periods, because they are stable liquids at room temperature and have high energy density — how much energy the liquid holds — in that state. These advantages make possible the more than 100,000 gas stations across the United States.

By contrast, hydrogen is less energy dense — a tanker truck of hydrogen gas doesn’t compare to the value of a tanker filled with gas. And a nationwide hydrogen pipeline infrastructure is unlikely to ever be implemented. Liquification can make hydrogen more energy-dense and feasible to transport by tanker truck. But hydrogen can be liquified only by cooling it to minus 423 degrees Fahrenheit, which consumes 30 percent of its energy during liquification, an immediate penalty on its use as a fuel. More hydrogen is then lost to evaporation. Large-scale, long-term liquid hydrogen storage and transportation is unlikely to be economical or practical.

The solution? Meet renewable dimethyl ether. This colorless gas, already widely used as a solvent, aerosol propellant, refrigerant and high-efficiency diesel substitute, liquifies with light pressurization at just minus 13 Fahrenheit, easily within reach of current tanker and storage technology. It can be sustainably produced from biomass, from carbon dioxide sequestered from industrial point sources or from direct air C O2 capture. Non-toxic and non-carcinogenic, it’s not a greenhouse gas and won’t deplete the ozone layer. If spilled in the water, it has no marine toxicity. If spilled on the ground, it harmlessly evaporates.

What renewable dimethyl ether does do, and exceptionally well, is store hydrogen, six atoms of it in each molecule. Actually, you might think of it as hydrogen delivery system. It can easily and safely be carried as a liquid in current-generation fuel trucks. With it providing a method to transport hydrogen, we need to be able to produce hydrogen from it at the proper grade for hydrogen fuel-cell vehicles. Los Alamos National Laboratory has a commercialization and research and development agreement with Oberon Fuels, supported by the Department of Energy’s Hydrogen and Fuel Cell Technologies Office, to figure out how to scale up hydrogen production from their renewable dimethyl ether. This is not just a science project, but a real-world system to produce hydrogen at commercial scale and get hydrogen fuel-cell vehicles on the road with urgency.

At Los Alamos, we use what’s called a steam-reforming process to extract the hydrogen from renewable dimethyl ether. The process relies on new technology to harness steam, releasing the hydrogen, producing fuel-cell grade hydrogen. We plan to scale up production to reach a capacity of approximately 55 pounds per day with our pilot reactor system. This is the first such system at this scale. We’re not just interested in creating fuel-cell quality hydrogen. We know we can do that. But we want to integrate all the parts of this steam reforming reactor system to be economically sustainable and commercially viable at scale. That’s the magic formula for getting this technology on the road and for building out hydrogen infrastructure, including hydrogen hubs. Over the longterm, powering renewable hydrogen production from concentrated solar arrays could create further clean-energy efficiencies. The advantages of gasoline and diesel are evident in every gas station on the edge of town, at every truck stop, and every remote corner of the country: It’s there, and it’s cheap. But for our climate and our well-being, that cheap abundance comes at an unsustainable cost.

In addition to producing fuel-cell grade hydrogen, renewable dimethyl ether can do everything petroleum fuels can do, and more, without the toxicity or the greenhouse gases. Getting it out on the road is a challenge that we are closer than ever to meeting.

Troy Semelsberger is a chemical engineer at Los Alamos National Laboratory. The Executive’s Desk is a guest column providing advice, commentary or information about resources available to the business community in New Mexico. To submit a column for consideration, email gporter@abqjournal.com.
 
If dimethyl ether can be and already is being used as a high-octane diesel substitute in internal combustion engines, I can't help wondering why it's considered necessary to add complexity (and reduce the total output energy through further conversions) by messing around with hydrogen fuel-cells at all...?
 
Great thread. High fructose corn syrup makes your guts better at absorbing food, and so makes you fat (possibly)

Although fat-rich diets have taken much of the blame for the rise in obesity, excess consumption of processed sugars, and high-fructose corn syrup (HFCS) in particular, is strongly implicated in diet-induced obesity.​
Taylor and colleagues’ study reveals that fructose has a previously unknown effect on the structure of the intestine (Fig. 1). Previous work had shown that HFCS promotes metabolic pathways that support the formation of colon tumours, so the authors wondered what consequences a HFCS-rich diet might have for non-cancerous intestinal cells. Taylor et al. found that HFCS-fed mice had longer intestinal protrusions — structures known as villi — and absorbed more dietary nutrients compared with mice that did not receive HFCS in their diet. Furthermore, fatty diets caused an even greater weight gain in mice if such diets also contained fructose than if they did not.​
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Figure 1 | Fructose-mediated gut changes. Nutrients in the gut enter the bloodstream after passing through cells in an intestinal protrusion called a villus. Cells at the tip of a villus have limited access to oxygen (a state called hypoxia), and they die for reasons such as energy depletion and oxidative stress. Taylor et al. report that, if mice received high-fructose corn syrup (HFCS) in their diet, they had longer villi and higher levels of lipids in their blood compared with animals that did not receive HFCS.

Write up Paper (paywalled)
Yup, soda is like steroids, but for getting fat.
 
If dimethyl ether can be and already is being used as a high-octane diesel substitute in internal combustion engines, I can't help wondering why it's considered necessary to add complexity (and reduce the total output energy through further conversions) by messing around with hydrogen fuel-cells at all...?
You should contact the guy at Los Alamos to find out. I would guess he would know the answer.
 
What We Lose When Companies Make Things Easier for Consumers
Companies are always trying to eliminate ‘pain points’ or ‘friction’ when we buy things. That comes with a price we may not realize.
BY KATE MURPHY

IN Silicon Valley-speak, “friction” is any physical or psychological barrier that might prevent a potential buyer from buying or using a good or service. Eliminating that friction, or “pain point,” often by way of technology, has therefore become the vaunted business model, if not the raison d’être , of successful startups and established companies alike. Take your morning cup of coffee. The friction of making it is removed by having a barista at your local coffee shop make it for you. Ordering ahead on an app takes care of the potential pain points of waiting in line and interacting with the barista. Instructing a virtual assistant to order your coffee eliminates the burden of tapping on your phone. And, if leaving your house seems like too much exertion, your virtual assistant can prompt a coffee machine in your kitchen to brew you a steaming cup, which, being a smart machine, will subsequently make your coffee when and how you want without you having to disturb your morning reverie at all.
It’s hard to think of any human activity today that has not been subject to the same diminishing degrees of friction. Smart entrepreneurs have striven to eliminate perceived pain points from grocery shopping, stock trading, home buying, bike riding, vacation planning and even finding true love.

Removing friction is undoubtedly a smart business strategy. After all, we humans are wired to preserve our physical, biological and cognitive resources, not to mention our time, all of which are woefully limited. And yet, there is increasing evidence that some forms of friction, rather than being impediments, are actually essential to our well-being. “I think the real danger of the frictionless economy is that at any moment it’s easier often to do the nonsocial thing,” says Nicholas Epley, professor of behavioral science and director of the Center for Decision Research at the University of Chicago Booth School of Business. Indeed, engaging with other people, and trying to understand their layered verbal and nonverbal messaging, is one of the most complicated things we ask our brains to do. So while apps and devices that reduce or eliminate that particular kind of friction can seem incredibly appealing, research indicates that a range of social interactions, including those with strangers or loose acquaintances (such as a barista who knows how you like your coffee) are fundamental to both our physical and emotional health.

Come on, smile
Dr. Epley and other researchers have repeatedly found that people wildly overestimate the friction, aggravation and awkwardness they will feel if forced to engage with others in commuter, retail, service and recreational settings. At the same time, they wildly underestimate how good they, and the people they meet, will feel afterward. Sociability is our evolutionary edge, and we are uniquely equipped with neural and biochemical reward systems that leave us subjectively happier and objectively healthier after connecting with others, even if it’s just a friendly smile, nod, or cheerful “Good morning!” “Little interactions with people add up and make a difference in how you perceive people who are different from you and how you perceive yourself as integrated and secure in the world,” says Katherine Fiori, professor of psychology at Adelphi University. For decades, research has shown that chance encounters during the most mundane, albeit now increasingly rare, activities, such as grocery shopping or going to the bank or post office, sharpen social skills, reduce anxiety, introduce novelty, spark creativity and create new opportunities. Virtual interactions, on the other hand, tend to do the opposite.

Defenders of frictionless commerce dismiss the idea that there might be negative consequences. “There is nothing but upside,” says Krishna Motukuri, co-founder and CEO of Zippin, a San Francisco-based company specializing in so-called grab and go technology that enables shoppers to just take what they want from stores and leave without interacting with anyone or even using a self-checkout machine. “We have been running Zippinpowered stores for more than four years now and we haven’t found a single person who comes back and says, ‘Oooh, I’d like to go back and stand in line.’”

Talking to strangers
Other proponents argue that reducing or eliminating interactions with vendors, service providers, random strangers or loose acquaintances gives people more time to spend with people they truly care about. But limiting your interactions to your inner circle has a serious drawback, beyond exacerbating “us vs. them” tendencies. “Generally it’s your close ties who you are going to get in an argument with,” says Dr. Fiori. “All interactions with weaker ties aren’t positive, of course, but on average, they are more positive than close ties.” Perhaps that’s why research shows people often share their most private thoughts and feelings with strangers, fearing blowback, judgment, gossip or drama if they told their family or closest pals.

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DANLIN ZHANG

Moreover, zipping through your day without social or other forms of friction may lead you to be less tolerant to the speed bumps, fits and starts inherent in intimate relationships. “You develop habits of relating in this frictionless way which brings you to the dinner table with the expectation that there, too, things are going to be as easy,” says Sherry Turkle, a professor, researcher and observer of the impact of technology on human relations at the Massachusetts Institute of Technology. In her memoir, “The Empathy Diaries,” Dr. Turkle describes the friction-filled experience of shopping with her grandparents in New York City in the latter part of the 20th century. Chat-ting with green grocers, butchers, fishmongers, and cheese and wine merchants was the texture and social grounding of people’s days. “You don’t want to glamorize it, but these were genuine relationships,” Dr. Turkle says. “They talked about their children, they talked about their lives, and that is what made up the fabric of living in an urban space.” Today, her grandparents would likely be using the self-checkout at the local CVS, just as Dr. Turkle does. Or worse, she says, “They’d be ordering things off Amazon and never leaving their apartment at all.”

Dr. Turkle is among many researchers who say the frictionless economy is contributing not only to the loneliness epidemic, but also widespread anger, oversensitivity and intolerance. A prime advantage of friction is you have to actively overcome it, which means you have to look up from your screen. You have to leave your personal bubble. You have to ask for help. You have to be polite. You have to listen. “When you talk to Alexa you don’t have to say, ‘Excuse me, I’m sorry to interrupt, but if you don’t mind, could you please tell me the weather?’ You just say, ‘Alexa, weather!’” says Nicholas Christakis, a professor and researcher who studies social networks and biosocial science at Yale University. “If developers required optimal social niceties, no one would buy the damn thing.” The catch, he says, is “the technology trains us and our children to be rude.”

Endearing bots
No one is suggesting that we ditch our technology and all go down to the river to wash our clothes or join communal farms. Well, some are. But Dr. Christakis says we need to be more thoughtful in the design of our technology so it reinforces rather than subverts our fundamental human sociability. For example, his lab has created robots that have endearing human qualities: They make goofy dad jokes and admit to fallibility. The result is that in experiments small groups of people who teamed up with those robots were demonstrably nicer to each other, more cooperative and more effective at completing tasks, compared with groups that were assigned to robots that were neutral or silent. “If artificial intelligence is designed sensitively to take into account our humanness, then it can contribute to our well-being, such as if it somehow facilitated chance encounters between humans,” says Dr. Christakis. “But if the technology is designed in a way that cuts against our natural humanity, our evolved ways of interacting socially, then I think it will contribute to a dystopian future.” Technology got us into this mess, maybe it will help get us out of it. Meanwhile, Dr. Epley at the University of Chicago advises that you actively seek out the friction that is your fellow man.

Take out your earbuds. Look people in the eye. Extend a friendly greeting. “It’s a little like exercise in that you have to choose to do it, and do it regularly, to appreciate the value,” he says. “That’s where the friction comes in: You have to make the effort. You have to say ‘Hello.’” Ms. Murphy is a journalist in Houston and the author of “You’re Not Listening: What You’re Missing and Why It Matters.” She can be reached at reports@wsj.com.

We are subjectively happier and objectively healthier after connecting with others, even if it’s just a friendly smile, nod or cheerful ’Good morning!’
 
If dimethyl ether can be and already is being used as a high-octane diesel substitute in internal combustion engines, I can't help wondering why it's considered necessary to add complexity (and reduce the total output energy through further conversions) by messing around with hydrogen fuel-cells at all...?
Fuel cells can get over 60% efficiency, whereas diesels are generally under 30%.
 

Esa mulls Solaris plan to beam solar energy from space​

Space chiefs are to investigate whether electricity could be beamed wirelessly from orbit into millions of homes.
The European Space Agency will this week likely approve a three-year study to see if having huge solar farms in space could work and be cost effective.
The eventual aim is to have giant satellites in orbit, each able to generate the same amount of electricity as a power station.
Research ministers will consider the idea at a Paris meeting on Tuesday.

While several organisations and other space agencies have looked into the idea, the so-called Solaris initiative would be the first to lay the ground for a practical plan to develop a space-based renewable energy generation system.
The programme is one of a number of proposals being considered by ministers at Esa's triennial council, which will decide the budget for the next phase of the space agency's plans for space exploration, environmental monitoring and communications.

Josef Aschbacher, who is Esa's director general, told BBC News that he believed that solar power from space could be of ''enormous'' help to address future energy shortages.
''We do need to convert into carbon neutral economies and therefore change the way we produce energy and especially reduce the fossil fuel part of our energy production," he said.
''If you can do it from space, and I'm saying if we could, because we are not there yet, this would be absolutely fantastic because it would solve a lot of problems."

The Sun's energy can be collected much more efficiently in space because there is neither night nor clouds. The idea has been around for more than 50 years, but it has been too difficult and too expensive to implement, until maybe now.
The game-changer has been the plummeting cost of launches, thanks to reusable rockets and other innovations developed by the private sector. But there have also been advances in robotic construction in space and the development of technology to wirelessly beam electricity from space to Earth.
Esa is seeking funds from its member nations for a research programme it calls Solaris, to see if these developments mean that it is now possible to develop spaced-based solar power reliably and cheaply enough to make it economically viable.

"The idea of space-based solar power is no longer science fiction," according to Esa's Dr Sanjay Vijendran, who is the scientist leading the Solaris initiative,
"The potential is there and we now need to really understand the technological path before a decision can be made to go ahead with trying to build something in space."

A key focus of the Solaris programme is to establish whether it is possible to transfer the solar energy collected in space to electricity grids on Earth. This can't of course be done with an extremely long cable, so it has to be sent wirelessly, using microwave beams.
The Solaris team has already shown that is is possible in principle to transmit electricity wirelessly safely and efficiently.
Engineers sent 2 KW of power collected from solar cells wirelessly to collectors more than 30 metres away at a demonstration at the aerospace firm, Airbus in Munich in September. It will be a big step up to send gigawatts of power over thousands of miles, but according to Jean Dominique Coste, who is a senior manager for Airbus's blue sky division, it could be achieved in a series of small steps.
''Our team of scientists have found no technical show-stoppers to prevent us from having space-based solar power," he said.

Dr Ray Simpkin, who is the chief scientist of Emrod, the firm that developed the wireless beaming system, said that the technology was safe.
''Nothing will get fried,'' he told BBC News.
"The power is spread out over a such a large area that even at its peak intensity in the centre of the beam it will not be hazardous to animals or humans."
The US, China and Japan are also advanced in the race to develop space-based solar power and are expected to announce their own plans shortly. Separately from the ESA proposal, in the UK, a company, Space Solar, has been formed. It aims to demonstrate beaming power from space within six years, and doing so commercially within nine years.

A UK government assessment, independent of the Esa plan, concluded that it might be possible to have a satellite capable of producing the same amount of electricity as a power station, around 2 GW, by 2040, which is in line with Esa's own estimates. But, according to Dr Vijendran, with increased funding and greater political support it could be done within a decade, akin to the deadline set by US President John Kennedy in 1961 to send an American astronaut to the lunar surface.
"It could be our generation's equivalent of the moon shot," he says.
https://www.bbc.com/news/science-environment-62982113
 
Dr Ray Simpkin, who is the chief scientist of Emrod, the firm that developed the wireless beaming system, said that the technology was safe.
''Nothing will get fried,'' he told BBC News.
"The power is spread out over a such a large area that even at its peak intensity in the centre of the beam it will not be hazardous to animals or humans."

Rarely have I read something that produced such a "that can't possibly be right" reaction, as the idea you could transfer 2GW from A to B and have it be safe to stand in the way. Not unless it's spread over such a wide area that the receiver array to collect it back on Earth would have to be impractically large. I actually began doing some "back of the envelope calculations" with some approximations as this didn't just feel wrong, it felt off by orders of magnitude. My first "guesstimate":

Since I didn't immediately have a number for what a safe level of human microwave exposure was, I went with the logic that a typical kitchen microwave runs uses about 1kW (with the microwave generation accounting for most of it), and is definitely not safe to be inside of. Let's imagine that 1kW is applied to 1 m2. OK, a square metre is a bit large than the inside of a microwave, but not massively so. We're talking what - probably still at least 10-20% of a running microwave oven? Definitely still in territory where I wouldn't buy it being non-hazardous. So receiving 1000 W per square metre of receiver seems way on the "too high" side of safe.

So how big does would our receiver station have to be for those 2 GW, at that power density? Easy calculation. 2 GW is 2 million kW, so at 1 kW per square metre we need a 2 million square metre receiver. Or 2 square km. The above article shows the proposed orbital solar array as roughly a square 1km on each side, so the receiver is already twice as big as the array, and that's with a beam intensity which seems dangerously high. This is in territory where it would make more sense to replace the receiver with ordinary ground based solar arrays. Twice as much area of panel, and a tiny fraction of the cost to build and maintain them compared to them being in orbit.

If anyone has a more credible number for a "safe" level of microwave power density I'd be happy to hear it. Wiki's entry on microwave power transmission talks about a human safe level way lower than that:

For earthbound applications, a large-area 10 km diameter receiving array allows large total power levels to be used while operating at the low power density suggested for human electromagnetic exposure safety. A human safe power density of 1 mW/cm2 distributed across a 10 km diameter area corresponds to 750 megawatts total power level. This is the power level found in many modern electric power plants. For comparison, a solar PV farm of similar size might easily exceed 10,000 megawatts (rounded) at best conditions during daytime.

Wiki offers 1 mW/cm2 as a human safe power density, but unfortunately doesn't give a citation for it. That works out at 10 W/ m2, so 1% of what I was taking as the limit above. And a proposed receiver area of about 78.5 km2, which is even more ridiculous when compared to just using solar panels on the ground.

Orbital solar arrays have been a popular idea in sci-fi for decades, and make for a wonderful plot device as something that could be misappropriated into a weapon. Or at least an accident waiting to happen to provide some drama for the plot. I'm not going to outright say that the writers of the above article are wrong that it can be made safe, but their claim that any practical sized system will have a beam that's too disperse to matter if it goes astray is spectacularly unconvincing.
 
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Rarely have I read something that produced such a "that can't possibly be right" reaction, as the idea you could transfer 2GW from A to B and have it be safe to stand in the way.
Remember the SimCity 2000 Microwave power plant disaster?
 
CRISPR, which is the hot topic in much of genetics including biohacking, is actually an inherited acquired immune system

I knew it was a bacterial immune system, I did not realise they were "remembering" the virus sequences in the bacterial genome.

CRISPR–Cas can function in nature as a rudimentary immune system. About 40% of sampled bacteria and 85% of sampled archaea have CRISPR–Cas systems. Often, these microbes can capture pieces of an invading virus’s genome, and store the sequences in a region of their own genome, called a CRISPR array. CRISPR arrays then serve as templates to generate RNAs that direct CRISPR-associated (Cas) enzymes to cut the corresponding DNA. This can allow microbes carrying the array to slice up the viral genome and potentially stop viral infections.​

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MIND & MATTER
SUSAN PINKER

How Happy Can a Windfall Make You?
How would you feel if an anonymous benefactor gave you $10,000 to spend within the next three months, no strings attached? Would suddenly being flush with cash fill you with joy?

That question sparked a remarkable study published this month in the Proceedings of the National Academy of Sciences. Lead author Elizabeth Dunn, a professor of psychology at the University of British Columbia, along with her doctoral student Ryan Dwyer, knew from prior research that there tends to be a correlation between receiving a sum of money and being happier. But those studies didn’t untangle the direction of causation—whether happier people made more money, or whether money made people happy.

The opportunity to dig deeper fell in their laps in 2020, when two anonymous donors offered to give Chris Anderson, the CEO and chief curator of TED, $2 million to distribute to worthy individuals around the world. Mr. Anderson then contacted Prof. Dunn. Might she be interested in studying the impact of these gifts? “Hell, yeah,” she answered. The TED organization, which ran the study, found participants for the “mystery experiment” by reaching out to English-speaking Twitter users. Individuals from three low-income countries—Brazil, Indonesia and Kenya—and four higher-income countries—Australia, Canada, the U.S. and the U.K.—were invited to participate in “a unique social science experiment… Before you are told the nature of the experiment, we will ask you specific questions regarding your behavior, background, personality and other matters,” the message began.

After weeding out those whose lives might be endangered by a sudden influx of cash, the study ended up with 300 participants. Two hundred were randomly chosen to receive $10,000 via PayPal. The remaining 100 respondents served as the control group. All participants had completed a baseline survey about their psychological well-being and annual earnings at the beginning of the experiment, then completed follow-up surveys one, two, three and six months after the cash was distributed. Members of the control group received $25 each time they filled out a survey.

The researchers found that, as might be expected, a big windfall made people happier than the drip-drip drip of repeated $25 gifts.

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TOMASZ WALENTA

But the money didn’t have the same effect on everyone. “The gains were greatest for recipients who had the least,” the paper found. People in lower-income countries who received $10,000 gained three times more happiness, based on the self-reported surveys, than those in higher-income countries. For recipients whose annual income was $100,000 or above, the gain in happiness was diminished. Comparing participants in the same country, those who made $10,000 a year gained twice as much happiness from the windfall as those making $100,000 a year. “This is consistent with a mountain of research showing that the more we have of something, the less we feel about increases. Those with lower income get a better boost,” said Prof. Dunn.

In 2021, four billion people worldwide lived on less than $6.70 a day. The new study suggests that if any of them got a cash gift with no strings attached, a smile would likely appear on their face. Perhaps such giving should become a Thanksgiving tradition, along with turkey and football. “My fondest wish is that people will emulate what this couple did,” said Prof. Dunn. For people who have money to spare, giving it away creates “more happiness than if you kept it for yourselves.”
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The most expensive drug in the world
$3.5 million per dose, and they still reckon it is ~$5 million cheaper than the current option.

On 22 November, the US Food and Drug Administration (FDA) approved the first gene therapy for the genetic blood-clotting disorder haemophilia B — a one-time treatment that costs US$3.5 million.​
Hemgenix — developed by the pharmaceutical company CSL Behring, based in King of Prussia, Pennsylvania — uses a modified virus to deliver a gene to the recipient’s liver cells. The gene codes for a protein involved in blood clotting called factor IX, which people with the disease are unable to produce.​
Clinical trial data suggest that the single dose of Hemgenix will provide people with moderate to severe haemophilia with adequate protection from uncontrolled bleeding for eight years, and potentially longer.​
CSL Behring says the cost is justified. In a statement, the company said that even at a cost of $3.5 million, Hemgenix could save the US health-care system $5 million to $5.8 million per person treated, because of its proven effectiveness at decreasing or eliminating the need for regular injections of factor IX. People with haemophilia B (who account for 15% of haemophilia cases) are currently given factor IX once or twice a week. The protein is required to form blood clots, but people with the disease lack the gene required to make it in sufficient quantities. If the condition is left untreated, people experience uncontrolled bleeding that can be life-threatening.​
“Living with haemophilia is all about where one is born,” says Glenn Pierce, vice-president of the World Federation of Hemophilia in Montreal, Canada. “In the US, the treatment of an adult with haemophilia B averages $700,000–800,000 per year. The high price of Hemgenix will pay for itself in a relatively short time, and assuming it lasts.”​
But scientists worry that the price would not be affordable in low- and middle-income countries, where most people with haemophilia live and where supplies of treatments and factor IX are often insufficient. “As new technologies such as gene therapy emerge on the scene, those who would benefit most can least afford to pay. We cannot leave the majority of the world behind,” says Pierce. CSL Behring declined to comment on the drug’s pricing beyond its public statement.​
The latest clinical trial of Hemgenix, which included 54 people with haemophilia B, reported a 54% reduction in the number of bleeding episodes per year, and 94% of participants discontinued any prophylactic therapy within two years of receiving the single dose. “The patients start making factor IX very quickly ... in seven to eight months after the single dose, for nearly all patients, the level of factor IX had stabilized,” says Andrew Nash, CSL Behring’s chief scientific officer.​
Even the lowest response in the clinical trial, a 10% increase in factor IX levels, is sufficient to prevent spontaneous bleeding, researchers say. But patients might require top-up prophylaxis treatments after injuries, or if they’re having major surgery and their factor IX levels are less than 50%.​
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A blood clot, which you cannot do if you have haemophilia
 
Cool picture of a blood clot!
 
I'm pretty chuffed. I've been talking about single-allele corrections/treatments for awhile now as a critical step in the future of medical technologies. Once you have one viable example, it's a field where innovation can chip away at other ideas.
 
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