I have sahara in my current game, shows up as expected and game runs fine, haven't tried reload yet. I suspect that if i did, 4/5 times it will CTD and 1/5 it will be fine -- this is how things have been with this mod for a while now, it doesn't CTD
every reload, but often. I'll edit this post if I get a successful reload in this game, now that I know sahara is here, so we can maybe rule that out as the cause.
I suspect its not any particular wonder but memory issue from pushing limits of civ 5 engine with many heavy mods, and this one perhaps heavier than most in all the visual goodies it adds to the map... just a hunch