With regard to the native Americans, I agree with you that forced assimilation was by no means the worst of what some suffered. However, I am not aware of any case where assimilated individuals of part-Indian blood were killed by government decree, whereas the Nazis went after any taint of Jewish blood and disregarded assimilation. There was no way to assimilate individuals of targeted ethnicities in Nazi Germany, save by the rare "Aryanization" certificate. I am not aware of federally sanctioned killing squads, for example, that went through towns in established states with orders to systematically kill individuals with specified percentages of native ancestry.
The 19th century Indian Wars were not accompanied by special government groups roaming through the Midwest & Eastern coast, meticulously sifting through parish records to find & kill all full-blooded or partial-Indians who might be the local mayor, or running a general store, or teaching the local schoolchildren. The US govt sought to eradicate any sovereign Native entities that interfered with land settlement and along with them any Native culture that would lead to resistance, hence the boarding schools for those children after the government decided to indoctrinate the children. The Germans went through their assimilated Jews (including many German citizens living in land continuously under control by Germany since 1871) and decided to kill them; no indoctrination schools for them where the children could be brought up as full Germans. All Jews had to be wiped out. For the exact parallel between the US to hold with Germany exactly, you'd have to show the existence of an organized effort to identify & kill all individuals of Indian ancestry in all settled states of the Union, and the US government never did this. It certainly wasn't an offense, for example, to fail to denounce your half-Indian neighbor to the New York City police so he could be taken away & killed.
Upon rereading your post, I think we are talking about slightly different things. You are pointing out that the Nazis liked to frequently label their ideological enemies as Jews, though the Nazis never labeled the Chinese (Communist or Nationalist) as "Jewish", so I think there are limits to which they would go publically. I'm pointing out that the presumption with individuals of Jewish ancestry is that they were automatically considered enemies of the state *regardless* of their ideology.
Now, I grant you, it is a staple of alternate history that if Hitler had won, he'd have gotten around to wiping out many other groups (Slavs) as well, so in the end, it might not have mattered except that certain groups were wiped out first, and they might all have been labelled "Jewish" in turn (well maybe not the "Asiatics").
As for more evil, I didn't mean to imply that, but I would say different from certain other situations, such as the Indian Wars in America, as I don't feel it is exactly the same. Pol Pot, as another example, was different in his own way (and some argue worse), and he managed to kill a significant fraction of his own countrymen, and he killed for pretty bizarre ideological reasons as well, but he didn't accomplish anything from the standpoint of foreign relations or military conquest. Therefore, I doubt we'll see anyone lobbying to play him, as he seems less interesting to many posters.
Anyway, to get back to my earlier posts, I still don't think the existing German government will allow the sale of a version of Civ with Hitler as a playable leader.