except in razing mecca we would probably get nuked by pakistan and maybe even israel and when and if iran gets nukes they would hit us for sure so all of the middle east would be a bunch of size 3 cities and fallout
Why would Israel nuke the USA if they raze Mecca? nuking Mecca is Israel's wet dream. more likely that if Mecca will be nuked by the USA, Israel will be blamed by the Islamic world.
If you want to decribe the Middle East on civ terms it will be a Israeli bomber that bombs the huge stack of anti-tank guns in Gaza and gets diplomatic penalties in most of the empires. Iran would be a theocratic-police state with vassals like Hezbollah and Hammas.