Gooblah
Heh...
- Joined
- Jun 5, 2007
- Messages
- 4,282
I'm thinking that the sickle cell mutation occurred after being subject to a malarial environment so did the disease have anything to do with "guiding" the mutation? Hmm... I wonder if there are differences in regional sickle cell indicating several similar successful mutations in different populations or the spread of one mutation altered later by region.
The mutation itself is random. There are no causes to it except a misplaced nucleic acid. The selection isn't as random, since the external pressures (in this case, the presence of malaria) selected those individuals with a mutation that afforded protection against malaria to reproduce.
Oddly enough, the sickle-cell trait is not dominant, but recessive. Thus, double recessives will die (sickle-cell anemia), and double dominants will die (malaria); heterozygotes have the largest chance of survival.