The one thing that worries me when I finally get an SSD is how my game install habits will affect it. I usually only have the games I am actively playing or about to play installed. Everything else gets uninstalled real lickity split. Since SSDs having limited writes, I figure it'd be, eh, detrimental to be installing and uninstalling dozens of games each year.
Easiest solution would be to only have the heavy duty games on the SSD, but I'd still run into the same issue, just with a smaller number.