In this one Daedric quest, there's this cave that has some Oblivion Realm elements to it (an isolated island, Oblivion briges over a black void). Anyway, there's this one room with a thing (looks like one of those wekland or alyied stones) that shoots out a huge ball of frost. It reminds me of the same thing in Legend of Zelda games where it would be in the center of the room and zap a laser at you - only the Oblivion version is more accurate.
Turns out, I had just finished an epic battle against 2 Frost Atronochs and 2 Clannfears. I turned around the hallway and went up to the door so I could replenish my health. Just as I peaked out, the frost ball hit me - game over.