In terms of natural selection I think we're pretty much done evolving, unless something triggers a collapse of civilization / mass population loss and we end up back at square one. We might start 'evolving' ourselves with technology or genetics in the future though.
What will finally wipe out humanity? I suppose the optimistic, ultra-long-term answer is heat death although that can hardly be called optimistic, depending on how you look at it. Honestly heat death would be such a depressing way for us to go out, in some ways I'd rather we bit the dust fighting off hordes of aliens or something, Private Hudson style.