Originally posted by FearlessLeader2
I have a stupid question:
Do mitochondria reproduce? Or are we going to someday run out of them as cells divide and split them up, and every human alive at that time will just keel over dead from the lack?
Follow-up stupid question:
If mitochondria do reproduce, how do they do it? Do they have little Star Trek replicators that always make them exactly the same, or little Star Wars cloning cylinders that make them exactly the same, or do they divide like all other life on earth, and occasionally suffer genetic modification via the transposing of base pairs during mRNA replication?
Stupid follow-up to my earlier stupid follow-up:
If the third method of mitochodrial reproduction is correct, then wouldn't the mitochondria in one CELL have different DNA, let alone the mitochondria in different organisms in the same species?
One last vastly ignorant stupid question:
Since everything we know about DNA and cell replication tells us that even 'identical' twins are different, genetically speaking, wouldn't it be the worst form of outright deception and disingenuity to even suggest that all human mitochondria would be the same if all humans could be traced back to one mother? I mean, wouldn't even bringing up such a thing in a public forum, as a means of trying to stifle the opposition in a debate be the worst sort of dishonest tactics and outright lying?
Not stupid, very valid. And misguided.
1. Yes.
2. By a similar process to normal cell division or mitosis.
3. No. In "Follow-up stupid question" you used the key term "occasionally". During division there is a small chance of mutations happening - but we are talking a real small possibility, and if it does manage to occur at best it is only likely to be one base pair that is different. And remember that each cell, and each mitochindrion, has started from the same point, that is the contents of the mothers ovum. The odds are in fact more likely that all mitochondria in one cell would be the same, or very, very similar.
4. Evolution has created a very efficient mechanism in replication, if mutations happened too often then there would be no consistancy and life would likely have never got going, at least not at a complex level. In normal DNA replication there are built in mechanisms that look for mutations and rectify them - not 100% reliable, but over a short period of time extremely so. Mitochondria lack this extra level of protection from mutation so therefore, compared with mututions in the nucleus, the rate of mutations in the mitochondria are more rapid - but still more likely NOT to happen. The actual rate of mutations is also fairly consistance, so by measuring the relative similarity and differences in mitochondrial DNA between individuals it's possible to calculate an estimate of when those two individuals shared a common ancestor. But also because of this faster rate, mitochondrial DNA is not useful in comparing different species that have common ancestors back in time.
Why? Mitochondria are more resiliant to changes in the DNA - they can keep functioning with mutations. Other proteins like hemoglobin are much less tolerant of mutations and so changes are much slower over time and they become better indicators of older evolutionary paths.
Going back a step or two, remember that the origins of my wife's mitochondria are from her mother (largely - it is possible for sperm to carry a very few mitochondria), and hers from her mother, and so on. The key cells are obviously those of the ovaries. The cells are exposed to much less cell division because by the time the girl-child is born, the ovaries have formed and await puberty to begin producing ova, but from what is already there. Elsewhere, cells are constantly dividing. So it would be fair to say that my wife may well have skin cells that have an increased chance of differing from her ovary cells due to sheer numbers of divisions, however the mitochondria passed on to our daughter will be either exactly the same as the zygote that became my wonderful wife (I think she was quieter and less bossy then!!) or very similar, differing in maybe one base pair.
From this it should be clear that following the path back into our history that a path of genetic similarity can be formed with some accuracy. The key issue being that yes mitochondrial DNA does get exposed to genetic muatation, but at a measurable rate and the chances of it occuring is not great (just better than normal DNA).
Just on a couple of other points I noticed in this thread, evolution does not just spit out a rabbit from a pig - the mutations in genetic code are subtle, longer neck, more colourful feathers, large brain case. For the most part a variation in genetic code would be instantly fatal, but occasionally the change produces a slightly different individual, if this change increases the individuals chances or living, and therefore mating, the genetic change can be passed on. This is how, slowly over time, evolution creates new species, or just a shift in the genotype of existing species.
Lastly, this is a pretty hot topic, it very quickly denegrades to name calling (seen it on other forums). And from both sides of the debate. Let's keep it going if that is people's wish, but please keep it civil - let the debate be on points of discussion.
Ado