: Georgia, Ukraine, Azerbaijan, and Moldova.
This paper reviews particular genes related to the physical traits and adaptation to the environment, including eye colour, skin pigmentation, hair thickness, vitamin D levels, immune system, body height, lactase peristence and lipid levels (influencing BMI and obesity risk).
Abstract
The arrival of farming in Europe beginning around 8,500 years ago required adaptation to new environments, pathogens, diets, and social organizations. While evidence of natural selection can be revealed by studying patterns of genetic variation in present-day people1-6, these pattern are only indirect echoes of past events, and provide little information about where and when selection occurred. Ancient DNA makes it possible to examine populations as they were before, during and after adaptation events, and thus to reveal the tempo and mode of selection7,8. Here we report the first genome-wide scan for selection using ancient DNA, based on 83 human samples from Holocene Europe analyzed at over 300,000 positions. We find five genome-wide signals of selection, at loci associated with diet and pigmentation. Surprisingly in light of suggestions of selection on immune traits associated with the advent of agriculture and denser living conditions, we find no strong sweeps associated with immunological phenotypes. We also report a scan for selection for complex traits, and find two signals of selection on height: for short stature in Iberia after the arrival of agriculture, and for tall stature on the Pontic-Caspian steppe earlier than 5,000 years ago. A surprise is that in Scandinavian hunter-gatherers living around 8,000 years ago, there is a high frequency of the derived allele at the EDAR gene that is the strongest known signal of selection in East Asians and that is thought to have arisen in East Asia. These results document the power of ancient DNA to reveal features of past adaptation that could not be understood from analyses of present-day people.
Here are some of the genes and alleles studied. I have inserted the links to SNPedia for easy reference. Note that rs7940244 wasn't on SNPedia, but I found a proxy in the same gene.
HERC2 (rs12913832 - eye color)
SLC24A5 (rs1426654 - skin pigmentation)
SLC45A2 (rs16891982 - skin pigmentation)
LCT (rs4988235 - lactase peristence)
NADSYN1 (rs7940244 - vitamin D levels)
FADS1 (rs174546 - LDL cholesterol levels)
EDAR (rs3827760 - hair thickness)
TLR6 (rs7661887 - immune system)
This graph shows the evolution of the various alleles:
The alleles for fair skin are in blue and green. Mesolithic Europeans had dark skin (only a few samples derived for SLC24A5). Neolithic farmers were usually derived for SLC24A5, while Steppe people (click LINK) were derived for both SLC24A5 and SLC45A2.
Blue eyes were very common among Mesolithic Europeans, while Neolithic farmers and Yamna people had mixed eye colours.
Lactase persistence only starting taking off in the Chalcolithic, but underwent a very strong positive selection since then.
Lipid levels constantly increased over time, as if food became progressively scarcer as the population grew.
The gene for vitamin D production has oscillated over time, but it looks like the recent selection has been against increased vitamin D production, probably because people got their vit. D from milk and drank more milk as they became lactose tolerant.
We detect a significant signal of directional selection on height in Europe (p=0.002), and our ancient DNA data allows us to determine when this occurred and also to determine the direction of selection. Both the Iberian Early Neolithic and Middle Neolithic samples show evidence of selection for decreased height relative to present-day European Americans (Figure 3A; p=0.002 and p < 0.0001, respectively). Comparing populations that existed at the same time (Figure 3B), there is a significant signal of selection between central European and Iberian populations in each of the Early Neolithic, Middle Neolithic and present-day periods (p=0.011, 0.012 and 0.004, respectively). Therefore, the selective gradient in height in Europe has existed for the past 8,000 years. This gradient was established in the Early Neolithic, increased into the Middle Neolithic and decreased at some point thereafter. Since we detect no significant evidence of selection or change in genetic height among Northern European populations, our results further suggest that selection operated mainly on Southern rather than Northern European populations. There is another possible signal in the Yamnaya, related to people who migrated into central Europe beginning at least 4,800 years ago and who contributed about half the ancestry of northern Europeans today9. The Yamnaya have the greatest predicted genetic height of any population, and the difference between Yamnaya and the Iberian Middle Neolithic is the greatest observed in our data (Z=6.2, p<0.0001, Extended data Figure 6). This observation is consistent with archaeological evidence that the Yamnaya were taller than populations contemporary to them43.
Fortunately ???
Guam?![]()
I give in. What's Guam doing in CEFTA?
edit: huh. http://en.wikipedia.org/wiki/GUAM_Organization_for_Democracy_and_Economic_Development
So were there only 4 apocalypse novels in the whole of the 1900's?
I'm assuming he was estimating based on all bars being the same size, i.e. 25%. It's quite likely that there are exactly 4 data points in this case, as the probability of getting an equal split gets smaller and smaller the more data points you have.No. That is a percentage. Here is the article.
Spoiler :![]()