I recently played an interesting American game, where I waited to see what I'd flip as my capital. It turned out to be Savannah, which was a bit meh, but I also flipped New York and Pointe-Saint-Anne. I gave back PSA to the English for peace, then redeclared and razed it later.
Founded Chicago in its normal spot, Denver in its normal spot, Los Angeles in its normal spot, and Mexicali at the mouth of the Colorado.
Later, I declared against France and razed New Orleans, because it would overlap a bit too much with Savannah to be optimal, and razed St. Louis au Texas as well. I founded Houston, which isn't a bad city. And then, finally, I got Vancouver from the English in a Congress.
So so far in the game, I have Savannah as my capital, LA and NYC as really huge cities, Denver and Chicago as production powerhouses, Vancouver, which isn't a bad city overall, and Houston, which is my economic and science 'capital'. Was pretty much running a cottage economy the whole game.
Oh yeah, and I forgot about Mexicali, which was just for teh lulz.