I find it interesting that Simón Bolívar returned from Civilization VI. Firaxis is full of surprises. This means Gran Colombia will return in the future too.
Let's hope so. I would love that they base it on overall Colombia though (from 1810-present), not just the short period were it was larger aka. Gran Colombia (1819-1831).
The fact that leaders are independent could help with that. We could have a more culture and agriculture centred Colombia instead of a militaristic one this time around.
Colombia (together with Argentina) inspired other Spanish colonies to declare independence and the Colombian Constitution of 1821 served as a blueprint for future constitutions in Latin America. Its also the oldest democracy in the Americas after the USA.
Moreover, Colombia was one of the first places in the New World to establish post-colonial State-run institutions such as schools, universities, museums and research institutes. The oldest museum in North and South America is the National Museum of Colombia, which is even older than the Smithsonian. The First Academy of the Spanish Language outside of Spain was in Colombia and the oldest astronomical observatory in the New World as well.
For those reasons Bogotá was a cultured City-State back in Civ5.
Also, Colombia is one of the major contributors to contemporary Spanish-language pop culture in the world. Colombian music, movies, series, etc. are consumed in Spain, Latin America, the Balkans, Israel, South Korea, Turkey, etc. This, in turn, has made it a significant tourist destination, with more foreign visitors than Brazil or even Perú.
I think it merits to have a future Colombia civilization centred on culture/tourism or whatever similar mechanic exists in the Modern Era.
The Torres del Parque buildings could work as the Wonder building for Colombia.