The Anti-Aging Thread

Narz

keeping it real
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I was listening to this audiobook in the car & thought I'd make this thread. I know there are a number among the anti-aging platform here (most notable El_Mac) so I thought I'd check in & see what everyone's regime is.

Personally aging offends both my vanity & my aspirations. Ideally I'd like to enjoy the benefits of experience while minimizing the effects of aging.

I try to imbibe a lot of anti-oxidants, as much sleep as my insomniatic self can muster & hopefully manage my stress well (I'm getting better at it). Nevertheless I definitely feel a difference in my 30's than a decade ago. Of course I'm a fairly imbalanced person at present, I'm hoping to feel more vital in my 40's than I do now. :)

Feel free to share any personal ideas or routines as well as relevant reading/viewing material. :)
 
I don't think there are many anti-aging here. Only many healthy (pun intended) skeptics.

You don't want to be like, say, Ray Kurzweil, so pathetically afraid of your own inevitable decadence and death that you keep making pipe dream predictions, or do you?
 
I dunno, I'm pretty afraid of my own demise. That said, I care less about living forever & more about staying younger. I'll be damned if I let you whipper-snapers surpass me. :D
 
Research on life extension is just that, at this point, research. It has yet to produce much beyond conjecture. A few years ago, for example, resveratrol was hyped, but a recent study suggested its effects were exaggerated.
 
I'm not necessarily just talking about pills. There's plenty of research on exercise for example & how it's protective of not only the body but also the brain.

Nutrition there is far less consensus on.
 
Mostly, you have to have to have the right genes. I am not saying correct eating habits, exercise, simply an overall healthy lifestyle can't do wonders, but unless it is backed by the right genetic foundation... No one lives forever. However, I'd like to be at least reasonably healthy and mobile when I get old. I wouldn't like to end up like some of the elderly people I see around me.

(The mother's side of my family seems to have genes for longevity - almost every one of them lives up to 90 years. My grandmother was over 90 when she died, my great-aunt is 92 now, and my great-uncle was ninety this year, and seems pretty healthy. Considering how unhealthily they eat and live, maybe I have a chance to celebrate my 100th birthday in 2085. Especially since I take after my mother.)
 
I am happy to respond to questions on this topic. I am aware that I have aberrant views, but I don't think that I am wrong. In fact, I am fairly certain that I am correct, and that it's an issue of perspective, mostly.

My view is that aging is something that can be 'cured'. In that, it has a scientifically possible solution, so that the phenotype of aging can be halted or reversed. In the meantime, aging is something that can also be slowed, in that it's possible to do things which will cause one person to have more 'negative symptoms' of aging than another. Both genetics and lifestyle matter.

Now, further to the idea that aging can be cured, it is my opinion that (unless we let the world go off the rails with ecological or natural resource concerns) it will eventually be cured. Eventually, there will be a cohort that is saved from most of the ravages of aging. Just before they're saved, though, there will be a cohort that dies fairly horrible deaths.

This means that if I want reduce someone's negative consequences of aging, I can do two things (and they're not mutually exclusive). Firstly, I can help them engage in a lifestyle that will slow the symptoms of aging. Secondly, I can help speed the quest of the (inevitable) cure. Lifestyle modifications are the low-hanging fruit. Speeding the science of medicine has the potential of having more people benefit from my efforts. If I buy a year while waiting for the science, the effect is awfully similar (personally) to helping move the science a year forward, but the mass effect is very different.

I've got some personal timelines. I never had hope of saving my grandparents. It needed a different world than the one we had. I do have a slim hope for my parents. I honestly think it's technically possible for society to develop therapies to slow/cure aging in time to bridge them. Is it likely? No, it isn't, because I don't have enough people helping me. Western society has a LOT of spare capital (in how we spend our luxury budget) and manhours, and I could certainly use more help.

What I hope is that people will think about how to spend their capital ($ and spare time). There're two direct ways to help make the cure for aging inevitable: help slow ecosystem wastage and help fund innovations/progress. Both direct and indirect effects matter! This creates synergistic efforts, and makes it more likely you'll help save more loved ones. My goal, and I believe it strongly, is that we should end the blight of involuntary death. Early on that list is the negative consequences of aging.
 
I'm not necessarily just talking about pills. There's plenty of research on exercise for example & how it's protective of not only the body but also the brain.

I don't think you need life extension as an excuse for exercise.
 
Anybody seen In Time yet?
I heard in this movie, people stop aging at 25 and must buy more time to live longer. In theory, the super rich are immortal. It sounds like an interesting concept.
 
I don't think you need life extension as an excuse for exercise.
That's true, there are a lot of benefits of exercise, including immediate gratification during & directly after. :)

El_Mac, you didn't address what you're actively doing now, that's what I'm really curious about in this thread. I don't think waiting for magic-bullet(s) is very proactive. Perfection seems to be another person who's claimed to be interested in not aging but he's also into fast food & microwave popcorn. If it's a serious goal you need a plan now because it's doubtful technology is going to be able to fully undo damage done while you wait.
 
Meditation apparently affects the shortening of telomers. Enhances the protective cap at the end and thus extending life a bit by delaying degradation of DNA.

There was also a hyped up cocktail for anti-aging by some Radman character but I'm unsure of its worth.

I'm more interested how we would strengthen the brain, incredible lifespans are meaningless without a working memory.
 
http://www.amazon.com/You-Staying-Owners-Extending-Warranty/dp/0743292561

I read the above book. It's massive. 400+ in textbook format so it's about 800(?) pages of material. They identified ~14 things that age people.

Cigarettes caused problems in 12 or 13 of those categories.

Reading the book I distilled the repeated principles down to about 5.

  • Eat a good diet. This means eating unrefined, unprocessed foods. Lots of fruits/vegetables. Have as varied a diet as you can as there's great nutrition in so many different foods that it's important to have a little here and a little there from day to day to weeks to months etc.
  • Sleep enough and sleep well. Get the right bed and make sure you are breathing well at night (not chronically snoring etc)
  • Exercise. The human body was meant to be in motion. You should be in motion, even if that means having a household set up so that you have to move around to get things done.
  • Meditate. Meditation was a very important and powerful anti ager in most of the categories, just as much as the above things. Meditation creates physiological changes in your nervous system that keeps you from dying from things among its other benefits.
  • Live a good lifestyle. Have purpose, have friends, have community, and keep your stress constructive (low stress is good, high stress can be mitigated if it's directed positively).

A very good TED talk on aging also pointed out that most all people are genetically predisposed to living to about 90. If you take good care of yourself, you can live that long, healthy and alert pretty much right up to the point of death. If you're dying at old age at 75 it's probably because you were sick and slow since you were 55. You don't want to die younger simply because it implies you are living worse while still alive.
 
On a slightly unrelated note... has there been any progress in cryonics, I mean the respectable kind? Or is it still just an expensive method of burial?
 
El_Mac, you didn't address what you're actively doing now, that's what I'm really curious about in this thread. I don't think waiting for magic-bullet(s) is very proactive.

IMO, merely taking care of one's own health is essentially waiting for a magic-bullet on this issue. That said, I agree that taking care of your own health is wise. I monitor my diet quite aggressively, though I don't follow calorie restriction. I endeavour to eat no simple carbs, to eat 8 servings of vegetable/fruit per day, balance salt and fibre intake, and avoid transfats. get an average of 30 min of aerobic exercise, some strength exercise, and work on manual cognition (i.e., physical skills). Additionally, I try to keep up-to-date on nutritional tweaking, and so I take salmon oil and vitamin D as a supplement. I also regularly ingest tomato paste, because I like the data on HDL. I don't take resveratrol. It's a potential nutraceutical, but I'm waiting for better data.

But I'm much more proactive than 'waiting for a magic bullet'. Like I said, I believe that the cure for aging is inevitable, unless we derail ecologically. For this reason, I try to think about my footprint, and try to reduce my footprint as well as helping educate others. I monitor ecological science as a leisure activity, so that I can aid this front in minor ways. Additionally, the 'magic bullet' is likely to have a cost, and so I am fairly frugal with an eye on investment and savings. I'd like to be able to afford whatever treatments that I need. So money, health, and ecology is how I increase the likelihood that a magic bullet will be available before I need it.

In addition to trying to be available for the treatments, I am pro-actively trying to actually speed the research. This is why I am so often asking people to help, and create synergies and their own contributions. Remember, I'm trying to save my friends and loved ones too. I can only really increase their odds by helping move the discovery dates forward. My calorie restriction won't help my parents or my wife's parents.

My efforts to speed the research have been compounding. In early days, I donated my own money to medical research & ecology charities. I assisted in setting up early SENS-based experiments, using my own time and money. I ran folding@home. But that's before I doubled-down on my contributions.

Since then, I've aggressively increased my biological and neuroscientific knowledge, using university-level resources. I currently try to consume scientific information not only professionally, but as a leisure activity. I just finished a contract for a medical research NGO in which I applied my skills at a significant discount to the market value of my worth, because I was trying to move the field forward. I have volunteered to participate in 5 scientific studies, and keep an eye out for more. I am currently working for a biotech startup (again, at a significant discount, but (I'll admit) a significant potential upside on my investment). For the last 4 years, I have been volunteering to tutor graduate students (in the biological fields) between 4-10 hours a week.

It's hard to make a perceptible contribution. However, the enormity of any contribution is astounding. If humanity speeds the development of the 'cure for aging' by one week, that would save almost a million lives. The more people who help, the more potential synergies are available. The earlier the generation of any research, the faster it can be integrated into a system that shows compounding interest. This is why I am so often asking for more help. There're lots and lots of ways to help. And there're lots of loved ones I want to see saved.

/thesis
 
Thanks for that & thanks for not taking offense (I didn't mean any).

When you say you avoid simple carbs I assume you mean refined sugar, even fruit & veggies have some natural simple carbs in them.
 
Yeah, I mean refined sugar. TBH, I don't really care about fruit sugar, I frequently snack on fruit. If I am making a fruit 'meal' (~400 calories or so), then I'll make sure to mix some healthy oils or protein into the meal in order to slow sugar digestion. But, it's not high on my list of things to worry about.

On the anti-aging front, there've been three 'recent' results that've shown good proof of concept. Narz already knows about some of them, but this is the right thread. In one, an compound was given to mice that effectively slowed down their rate of aging. It extended their healthy lifespan after they were already middle age. In two others, the symptom that was associated with aging was treated (these are things that partially cause our own aging) and reversed, and then the phenotypes of the mice reverted to a younger phenotype. It's not just that the accelerated aging was 'halted', but 'reversed'.

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.
nihms127666f1.jpg


In this paper, they caused a portion of the cells that gets 'older' with cell division to revert into a younger version. The individual cells were made 'younger' in an important way (the way that allows them to keep reproducing/dividing for longer). When the cells were made younger, the animals became younger.

Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice

This last one is a bit technical. Certain cells in our body will 'age' more quickly than others in a tissue, and this causes the cell to kill itself (apoptosis). However, in the process, these aging cells release inflammatory factors that contribute to other cells around them becoming distressed and aging more rapidly. What this group did was design an experiment where they could induce the 'dying' cells to die more cleanly/rapidly and this reduced the negative effect on the surrounding tissue.

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders


Like I said, these are just proof-of-concept studies, and don't actually recommend specific treatments for people. However, they do provide a hint that (a) pharmacology can slow aging, (b) inducing telomerase temporarily can 'reverse' some of the symptoms of aging and (c) 'cleaning' aging tissues can relieve aging-stress on the remainder tissue.

Like I frequently say, it's the rate of research that's going to matter.
 
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