We know that drug stimulants are responsible for people committing crimes, so I would say yes, but I would not say its systemic. Lets say that as of tomorrow American law stipulates that drug use is no longer a crime, you can use drugs as you please. Even if people are not locked up the social consequences of taking drugs is apparent, drug users would most likely not turn up to work, or work unproductively resulting in dismissals, personal relationships are destroyed, drug financing is required to fund the habit, the list goes on.
Adding to what you say:
I think negative effects of drugs are more related to the basket of cultures in a country (all the sub-groups, and aspects) than by restrictive and "law and order" actions (also one of the cultures in that basket of a country) by the country/state government.
If you look at the facts, the frequency of use, the death rates, everything in fact, it is not about availability.
What I can imagine for some drugs (could not find studies on that), is that whena country changes from a restrictive regime to a free regime, that you get a spike, before the amount stabilises again to its cultural frequency.
I can tell a whole story about the Netherlands and especially Amsterdam where I live now for 63 years... drugs were all over the place since my secondary school time, just like fish-nets, green tea and apples at school feasts.
But I digged up just top of Google a story on Columbian drug farmers: Do those farmers use it themselves the way we use it ?
There's more cocaine being
manufactured in Colombia than ever before. You see fields spread sporadically across the countryside, but once you venture more inland, they are everywhere. I once visited an area close to the city of Cali where there were marijuana and coca fields as far as the eye could see. Everyone in the local community seemed to be involved in the production or sale of cannabis and cocaine.
But no one uses the products themselves—not even André. His dream is to become a pilot, so he's saving up for his certificate.
https://www.vice.com/en_au/article/...ured-the-world-of-cocaine-farmers-in-columbia
Could me a misleading story ofc... so let's look at global figures of the death rate from drugs in Colombia compared with other countries:
You can see it is significant lower than most other countries in the world I hovered with my cursor above Columbia to highlight it).
And you can also see how low the Netherlands is (despite all the cannabis-paddos coffeeshops and the enormous amount of party drugs produced and sold here).
And let's look at another common drug: alcohol. Available (almost) everywhere for (mostly) little money.
(and alcohol can be a real job security and family destroyer with domestic violence)
https://ourworldindata.org/substance-use
The link to that site where you can look at countries and also the change over time.
What is very important (I think) is that a culture "handles" the too big negative side effects that can happen.
Just like you teach your children or encourage settings where they can exchange safely "best practice" (parents, schools, group-friends, etc) to be aware of snakes in this area, or bears in another, or car traffic in urban areas, or etc.... teach the allround awarenes, the effects, the risks, etc, and have traditions that "handle" it.
Whether making drugs freely available in the US would work to lower the death rate, the social disruption rate... IDK.... too far from my bed.
So many people in the US with taboos, with much of a restrictive culture, with wanting to punish all the time... to separate all the time.... just too far away from my reference feeling.