@TruthyThis is an A-B population comparison isn't it? Not particular A and general A comparison?
Oh yeah, that was a typo. I meant to say the probability in population A is 0.3 and the probability in population B is 0.7. I didn't realize it was a typo when you first quoted it two days ago.
I believe the opening of your post are consist of how the theory of race classification based on genetic are build and developed until its most contemporary state (UFG clustering), which also increased the accuracy of the classification. You also pretty much coined the importance of genetic classification in biomedical field. However the point of our discussion are mostly at the follow up commentary and I will answer it simultaneously.
Yeah, Fst is still used for a lot of things, but for creating clusters, unsupervised fuzzy clustering is more popular nowadays as far as I know.
There's another complication in the clustering I didn't mention before, but probably should have. The loci used in population structure research usually don't directly code for phenotypes, like skin color. They're actually from non-coding regions usually. So if you were wondering "how much of the variation between populations that these studies find is just unimportant stuff like skin color?", the answer is that I don't think many people directly use those parts of the genome (however, Lewontin did use loci from coding regions in his 1972 paper).
But then you might also wonder "if these studies are mostly based on non-coding DNA, how can the clusters even mean anything with respect to race?" Well, the clusters sort of align with the traditional concepts even though you aren't just checking phenotypes. Also, there's a misconception that non-coding DNA is "junk DNA." It's not known exactly what large swathes of the genome do, but a lot of non-coding DNA regions are known to do
something. For example, they can affect transcription factor binding, which can impact whether a gene is transcribed (i.e., converted into a protein). Overall, it seems very likely polymorphisms in non-coding regions do affect observable outcomes, in addition to being correlated with polymorphisms that code for observable traits.
Look, we can surely classify and categorized people based on their skin color, their geographical origins, their nationality, their ideology, their genetics structure and many other variable that you can or cannot imagine, but such classification are pointless if it doesn't follow the mean to classify it. Classifying human based on their genetics loci may prove to be fruitful and true for biomedical reason, but it doesn't prove the sociocultural significant of race classification.
I think I agree with this.
As an aside,
here's an interesting article from 2014 arguing that clustering doesn't support race realism. Lewontin is actually one of the authors (the dude's still alive; he's 90). For one, they argue the term "clinal class" some people use is just a euphemism for "race" and it's oxymoronic. They also argue that traits used in the traditional concept of race often don't covary (e.g., maybe skin color and hair texture). But I dunno, I disagree with some of what they say. They're sort of vague and hand wavy a lot of the time.
Can we argue that the socialcultural classification of human based on skin color, for instance black and white people, are truth based on how science recognize the difference level of melanin between these two human category (white lower level of Melanin, while black is higher)? The premise of that both skin color have different melanin level are true, however to conclude with that premise to approve the validity of the traditional sociocultural black and white category is incorrect. These two are not related.
So do the premise of how human can be classified genetically doesn't prove that the traditional category of human is right in a sociocultural level. It maybe have its function and benefit in biomedical, however it doesn't mean bringing this category to the sociocultural level is more sound than categorizing people based on their eyes color for instance, because both are equally pointless.
I agree, though to be fair, if you use someone's membership in a cluster you get a lot more information than just skin color or eye color.
Today science is believe to be an absolute measurement to justify nearly everything, while it has its limit. With genetic science giving a platform for the kind of people that believe that race and cultural classification are biological, this will give them the platform to believe that the (unequal) diversity of races and culture were evolutionary. This can be anytime used to give justification for any prejudice action when it needed.
A lot of the other posts in this thread make me worried.
The reality of human can be classify by genetic group explain nothing but the reality of human can be classify by genetic group. We may only can benefit only to the term that related on this reality, it is not explaining any socio or philosophical reality of human classification.
It is a 1+1=1+1 kind of thing
I'm not sure I understand.