Back when I was doing the home business thing (had three going at once - typing, crafting, and teaching music), it wasn't a case of having regular days off each week. There were certain days or weekends during the year that I decided I would not work - Halloween, Christmas, New Year's, the two weekends a year when I attended science fiction conventions (whichever weekend in July we had the Calgary SF convention, and Thanksgiving weekend in October), and the two Saturdays each year when the local SCA branch put on feasts.
These home businesses were seasonal, which meant several months of being extremely busy, and then downtime. I tried to arrange things so absolutely everything wasn't happening at once, and still get some time off.
Time off turned out to be January and when we had summer heat waves (not much typing to be done in January and after the October-December madness I needed that month); the summer time off was because it's difficult to do needlepoint for 10 hours a day with sweaty fingers. I'd push it as hard as I could, though, to be ready for the fall and winter craft fairs and custom orders.
Things didn't always work as planned, of course. I remember the times when a typing client dropped by and found me in my kitchen apron, making desserts for the Harvest Feast or Silver Arrow feast, or already in my medieval costume. There was one occasion when the only possible drop-off was for the clients to come to the church hall with their papers. They got quite an eyeful, with several dozen people all wearing medieval outfits from a variety of cultures and centuries.