kieranjtaylor
Chieftain
The Apostolic Palace isn't a shrine. The Catholic shrine is the Church of the Holy Sepulcher, if I remember correctly.
in regards to the Apostolic palace (which the Sistine Chapel is a part of) i would say St. Peter's Basilica is the shrine infact the shrine to saint peter is inside of it all of which are part of the Vatican.
Archbasilica of St. John Lateran is the Cathedral for the Bishop of Rome as such it is the most important in terms of rank in the catholic church and the popes used to reside at the Lateren Palace near by (a former Roman palace and a gift to the Bishop of Rome from constantine), but due to the vast appeal of the 4th century "old St Peter's Basilica" (not a cathedral just a massive church) built by saint Constantine on the grave of saint peter it has immense pilgrimage properties so much so that by the 5th century the popes moved from there spiritual seat of power and authority to a Papal Palace next to St. Peter's, even now Archbasilica of St. John Lateran is the official seat of power and still the highest ranked Basilica in Rome yet i bet most catholics don't even know it, that is a massive hint at how important this site is to the church and its followers.
also the holy Sepulchral is not a catholic shrine it is a pan-Christian shrine but yes it is the most important of the Christian pilgrimage sites but for game i think St.Peters and Hagia Sofia are better although i also agree which was earlier mentioned im not to comfortable with protestant holy city a key tenant of protestantism is the bible as oppose to church, maybe instead of the wonder being a cathedral it is actually a book.
to the canadian who doesn't like naturally angry Muslims, calm down don't lose your temper about.