Crack cocaine is the most addicting form of cocaine,[1] and it is one of the most addicting forms of any drug[1]
Crack cocaine is a substance that affects the brain chemistry of the user: causing euphoria,[4] supreme confidence,[5] loss of appetite,[4] insomnia,[4] alertness,[4] increased energy,[4] a craving for more cocaine,[5] and potential paranoia (ending after use).[6][4] Its initial effect is to release a large amount of dopamine,[2] a brain chemical inducing feelings of euphoria. In addition, smoking freebase cocaine releases methylecgonidine into one's body, something which insufflating or injecting powder cocaine does not do.[2] Methylecgonidine is a methylated form of cocaine in much the same way that methamphetamine is a methylated form of amphetamine. The high usually lasts from 5-10 minutes,[2][4] after which time dopamine levels in the brain plummet, leaving the user feeling depressed and low.[2] When crack is dissolved and injected, the absorption into the bloodstream is as rapid as by smoking,[4] with similar euphoria (assuming it's among the purer forms of crack).
When large amounts of dopamine are released by crack consumption, it becomes easier for the brain to generate motivation for other activities. The activity also releases a large amount of adrenaline into the body, which tends to increase heart rate[8] and blood pressure, leading to long-term cardiovascular problems. It is suggested by research that smoking crack or freebase cocaine has additional health issues beyond other methods of taking cocaine. Many of these issues relate specifically to the release of methylecgonidine, and the specific effect of methylecgonidine on the heart,[8] lungs,[9] and liver.[10]
Toxic ingredients - As noted previously, virtually any substance may have been added in order to expand the volume of a batch, or appear to be pure crack. Occasionally, highly toxic substances are used, with an indefinite range of corresponding short- and long-term health risks. If candle wax is bought (as a form of fake crack), it will burn in the pipe as a noxious smoke. If macadamia nuts are bought (perhaps during a police sting that escaped arrest), they will also burn in a crack pipe, producing a noxious smoke.