azzaman333
meh
On average, about a 4, right now somewhere between 1 and 2.
And that has sunk to a 1.
On average, about a 4, right now somewhere between 1 and 2.
10 about 10% of the time.
9 about 50% of the time.
8 about 40% of the time.
Been like that for the last 5 years.
Sure!45-10?
Sure!Who cares about the outcome of a football match? In fact, why rely on anything outside yourself to make or keep you happy?
I love mornings, everything seems better. And there is even some snow outside!
3
As you're aware, nobody knows. All that is known is that certain medications, such as lithium salts for bipolar patients, alleviate some or most of the symptoms. If I remember correctly, you did try a large number of medications when you were younger and found that none of them were helpful - am I correct about that? If so, your decision is perfectly rational; you should do whatever works best for you.What is "chemically balanced" exactly? I hear these phrases "imbalance", "balance" tossed around with no scientific definition.
I think you're claiming that article debunks the notion that depression is largely genetic. I looked at it, and it doesn't seem that's what it's really saying - it makes much narrower conclusions.So much stigmatization of the mentally interesting (to use the Simpsons line) and so much focus on debilitating effects... if it's really so damaging & largely genetic (which is bogus but a common belief) maybe we should ask ourselves why were such personalities were selected by others for breeding in the first place? Perhaps being nuerotypical (whatever that even really means, as if anyone's "normal" if you really get to know them) isn't such a particularly strong survival trait after all.
Isn't that a charmingly optimistic thought.
(If all women, some in particular, were to disappear right now, I'd up my current euphoria status to 7 at least.)
Sorry, I do not want to throw cold water but how do you know that even worse one(s) will not take the place...
I have a college I used to like but recently he has turned into almost complete nut...
You mean a colleague?
And I meant all women. If I were religious, I'd have to believe they were created just to make men feel so bad about themselves that they would tear their hair out in desperation and scream "Why god, why...?!"![]()
(If all women, some in particular, were to disappear right now, I'd up my current euphoria status to 7 at least.)
really? mine would drop significantly if there wouldn't be any women left... I would get thouroughly confused who to impress and you know.....
Actually Lithium did help a bit, the only one out of 19 or 20. However, it slowed me down a bit, a bit being unacceptable to me. I'd rather be more scattered & unstable with higher energy.As you're aware, nobody knows. All that is known is that certain medications, such as lithium salts for bipolar patients, alleviate some or most of the symptoms. If I remember correctly, you did try a large number of medications when you were younger and found that none of them were helpful - am I correct about that? If so, your decision is perfectly rational; you should do whatever works best for you.
To each their own. I'm certainly glad to hear your depression is better. Depression is so miserable I can't fault anyone for taking whatever measures they can to releave it.Since everyone's biochemistry is different and nobody really knows the biochemical basis for depression or all the variants of it, medication is just a crapshoot. I would argue it's a crapshoot worth taking, though - medication has noticeably improved depression in me, my dad and several of his siblings, his mother, etc. I can't wait until we actually understand the genetic basis of this seemingly hereditary, medication-responsive form of depression, and how that differs from the genetics of people who fail to respond to medication.
I suppose I am coming at things from my own perspective, personally I do not believe it is my genetic destiny to be depressed, that is to say I nearly all of my depression is related to circumstances. Others seem certain that their depression is largely hereditary. And perhaps we are both right. I personally think more people are depressed now than need be but perhaps some in inevitable regardless of circumstance. I find it hard to believe that major depression is built into an genome (it seems like such a maladaption) but I could be wrong. In certain circumstances I've realized, depression could be very adaptive. When you don't know whether to fight or flee & any wrong movement could be fatal a hibernation type emotional response could be helpful.I think you're claiming that article debunks the notion that depression is largely genetic. I looked at it, and it doesn't seem that's what it's really saying - it makes much narrower conclusions.
Apparently there's a serotonin transporter gene, 5-HTTLPR, for which one allele (denoted s) is correlated with higher rates of depression. The researchers found that people with this allele who grew up in supportive environments had markedly lower rates of depression than those who had the allele and an unsupportive family.
No surprises here - it's well-understood that mental health problems are the product of interactions among many genes and environmental factors. Supportive environments do decrease the odds of experiencing major depressive episodes among genetically susceptible individuals. But even well-supported genetically susceptible individuals are much more likely to experience depression than the general population.
There might also be differences in how much the environment matters based on which specific genes are present in a given depressive patient. There are almost certainly a large number of genotypes that can cause depression, and they may differ markedly in how powerful of a response the patients experience to environmental factors. All these researchers found is that one specific variant, depressive patients with the s allele in the 5-HTTLPR gene, do respond strongly to environmental factors. Other genes (or combinations of genes) associated with depression may lead to different environmental reactions.
I for one am depressed, as is/was my father, grandmother, and great-grandmother, and possibly even great-great-grandmother (she showed classic signs although psychiatry didn't really exist for her generation). All of us were raised in very supportive environments, but all of us developed depression anyway. I hope someday soon that I can affordably get my genome sequenced, along with others in my family, so as to better understand what happened.
tl;dr: Depression definitely has a strong genetic basis, but environmental factors matter too, and they may matter differently for different types of depression