In Friends' defense, it was never meant to be poignant AFAIK. Scrubs perfected that hybridization.
I'm almost through a re-watch of House. I kept putting it off but decided I'd finally get around to it. After having watched it more than once you notice repetitive lines in the script but it's not a big deal as it deals with substance (literally and metaphorically) pretty well.
But in anticipation of almost being through with it, I started watching Fresh Prince of Bel-Air for the first time. Only four episodes in. It has some funny moments in each episode but it keeps randomly breaking the fourth wall and the camerawork is... not the best. It's videoed like shaky home camcorder footage.