I think it is very fair to say - going by a number of things, although on my part mostly by discussing stuff about physics with physicists who happened to have been at my philosophy lectures - that physicists tend to approach the issue as if the human observer is a single point with observing powers, ie *almost* nothing there accounts for stuff in the observation. At best - again, in my own experience - the philosophical angle for them is limited to stuff about the senses defining the input. But this is only the tip of the iceberg, philosophically, and the one obvious thing here. Below that there are endless complications.
While most people do seem to approach this as if there is some vast number of unknowns just to the other side of the observer, imo reality is that there is at least an equal number of unknowns inside the observer.
Ultimately, I tend to agree with Socrates regarding physics (which he did argue against including in his school of philosophy - what later became Plato's Academy). Socrates used the example of astronomy and said that it is more important to examine the meaning of relations instead of the specific case of relations in the outside world. Although unlike Socrates I am of the view that the meaning of relations, terms, notions, of anything, is about the mind and likely has no actual tie to anything external (ie all external stuff are not an approximation but a translation on an inherently different plane). Instead of "translation" I could also use "unwilling/inevitable projection". (at least according to Plato, Socrates was of the view that some infinitesimal tie exists between reality and human thinking about it)
To a degree, though, this isn't just about sciences that have the external world as their subject. It is also true in math. For example, while it is great to know (eg) the pythagorean theorem, that it is true in euclidean geometry has imo meaning which is ultimately not about math but the deeper human mental world (like anything else which holds true on some axiomatic system). In this sense it is a bit like a human being content that they can walk (as they should be), instead of examining how exactly they are able to walk: if your goal is just to leave the room, it makes no sense agonizing about how you are even able to.