Hello, long time fan, first time poster. First of all, let me tell you that after all the time I spent playing RoM+AND it's become my default civ4 playing mode, it's just so good. Anyway, on to the direct reason for my post.
Since I've made the change to AND 1.64 I can't finish any game without it being abruptly ended by a sort of unavoidable CTD. I tend to play games that last well into transhuman era, which means researching Mass Media along the way. I've done some testing in my last 3 games, and this particular tech seems to be their killer.
Game 1: Became unstable after researching some modern era tech, I didn't really pay attention which tech it was at the time, but later experiences suggest Mass Media. The game crashed some time after the tech was researched and the latest autosave crashed one turn after loading. I figured it was just some random bug and started over.
Game 2: With 1 turn left to research Mass Media it became a very clear case of "press enter / receive crash". The game gave me the description of the newly researched tech, asked me for the next one, asked me to set production in all cities that have just finished building things, and then it froze for a second and crashed. When I'd changed the tech to be researched to anything different I could keep playing without problems. When ~20 turns later I tried to go back to researching Mass Media, BAM! The exact same CTD routine. When I tried to add Mass Media by means of the worldbuilder the game crashed on the beginning of the next turn. I could probably still win that game by leveraging my already ridiculously superior military tech (no tech diffusion in this game), which is why I've called those CTD's "sort of" unavoidable, but it really isn't my playstyle. Still hopeful that the issue could be randomly avoided I started over.
Game 3: This time after researching Mass Media the game didn't crash on the next turn. No, it crashed the turn after that. In related news, on the turn the game crashed it apparently also made an autosave - the game crashes after loading it, while the one before that (also before finishing the research on Mass Media) works just fine.