Within the Americas there's very significant variation in the fate of native peoples in terms of displacement and marginalisation.
At one end of the spectrum you have the Guarani in Paraguay whose language is the official and most widely spoken language there Paraguay, including by people of Spanish rather than indigenous background. At the other end you have the various groups who were completely wiped out.
I get the impression, just based on the contemporary nature of the Americas, that more severe decimation and destruction (physical and cultural) happened in North America, the Carribbean and the Southern Cone of Latin America, but I don't have any actual evidence or research on that.
But generally: being on land Europeans wanted badly and could occupy easily was worse for you than living somewhere marginal or defensible. Another example is Indigenous Australians vs Maori in New Zealand.
It depends on how badly Europeans wanted what was there. In a number of places the Indians were essentially enslaved, but enough of them survived so that their culture and language had chances to survive. Other places were inaccessible and undesirable enough so that they fell through the cracks. But often the people in those regions were people driven out of other areas.