Yes.
A failure to be in a fulfilling relationship is nowhere near as much suffering as someone who had to flee their home after seeing their family chopped up.
As I said to Mouthwash, attempting to equate the two or throwing up your hands in a sort of "who among us can judge" strikes me as somewhere on the continuum between ignorance and sociopathy.
Though I have no will to approach this as something about Mouthwash (given the implications for alarming lack of empathy towards Palestinians), I also am of the view that suffering is something very particular (if we aren't talking about extremes!). Psychological parameters may cause one to feel great pain over seemingly insignificant - or relatively not that dramatic - states.
Of course, if we go to extremes, as always relatively is diminished, and I think virtually everyone would agree that it is rather better to be alone than having had your arms cut off by belgian-run askari or some such in Congo.
There is the famous quote by the stoic Epictetus, that "one suffers not due to what happens to him, but due to how he regards what has happened".