I got the oddest message when trying to open this:
However, pushing continue did take me to the game. I'm currently trying to get through a recalc and I figure it's going to take more time than I have to be awake tonight to get through it.
Still, this is by far the latest game save I've ever seen. Simply amazing! Late stage Galactic era... wow. I'm going to hazard a guess and say that the overloaded integers are having a heyday with your game at this point and that could have a lot to do with the bug as reported. Sorry I can't do much more tonight on this one.
EDIT: Actually, the recalc completed and I was able to diagnose the hang. But the fix is going to be tricky and will take more thought than I can quite work out at this time. Apparently you're national culture level (or rather the next expected necessary amount for your leader to level again) has exceeded even the limit of unsigned long long!!! So basically what this means is that we're going to have to use some more breaking down in the math so that we can enable things to progress further in your game and others that reach this point. I was a bit worried this might be possible. I doubt it can be fully addressed before the release but I'll see what I can do tomorrow on the matter. I have given some thought as to how this can be addressed if it becomes a problem but not enough to implement yet